Problems in sexual life are one of the most frequent diseases for men, especially in declining years. According to statistics, about five percent of 40 years old and twenty percent of 65 years old men have problems with erection. Also, the insufficient erection and evanescent dysfunctions became a trouble for more than 50 percent of 50-70 years old men.
However it is not the sentence. In most case it is possible to treat this man's disease. The fact that one can easily struggle the problems with erection becomes more widespread day by day. A lot of sick persons trying to find the cure, and they really come back to common sexual life and the reason is successful healing of ED.
Viagra, Levitra and Cialis
At the present moment there are 3 preparations that should be taken orally and are approved by FDA. All these medications are made for ED fighting. They are: sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis). The main aim of these pills is to stop ferment phosphodiesterase type 5 (PDE-5). By their nature they belong to the inhibitors called phosphodiesterase (PDE).
The first and best of all known medication of such kind was Viagra. It was officially approved as a powerful preparation that treats ED in March 27, twelve years ago. The company that begins to produce Viagra was Pfizer.
After Viagra, Levitra was the next preparation that hit the shelves of drugstores in USA. It was also approved by FDA, but much later than its main competitor – in August 19, 2003. Levitra is produced by Bayer Pharmaceuticals Corporation.
Cialis was the last medication that appeared in pharmacies and effectively fights with ED. It was endorsed by Food and Drug Administration in the end of November, 2003. Cialis is produced by Lilly ICOS LLC. One of the most important preference of this kind of medications is that you can control the erection and it never appears without preliminary sexual stimulation. In the case when you are not stimulated the drug stays inactive. Viagra, Levitra and Cialis are prescribed to be taken orally anterior to the intended sexual act in order to make blood go into the penis in reply to stimulation. But in spite of the fact that all abovementioned medications belong to the similar kind of drug, they are all have significant differences, which can affect safety, feature, lifetime and finally the public reputation of particular drug
How does it work?
Those medications that belong to the PDE-5 inhibitors don't simply provide an erection, but change the reaction of man's body to veneral excitement. They intensify the effect of nitric oxide, the chemical agent that is secreted in the period of sexual stimulation. This chemical produces muscles reveling in virile member that increases the amount of blood enter the penis.
Productivity of PDE-5 Inhibitors
All three PDE-5 inhibitors, Viagra, Levitra and Cialis, have shown perfect effectiveness. Viagra's percent of performance (84%) is a little bit higher than Cialis (81%) and Levitra (80%).
Pharmaceutical Forms, Commencement of Action and Continuance of Effect
If we begin to compare all three medications, we will find out that Viagra and Levitra have very few differences due to their structure, while Cialis has very significant distinctions with a view of molecular lattice.
Viagra: 100mg, 50mg 25mg tablets
• Commencement of action: 30 minutes (works slower in the case when taking during the meal )
• Continuance of action: 4 to 5 hours
Levitra: 2.5 mg, 5 mg, 10 mg, 20 mg tablets
• Commencement of action: 25 minutes (works slower when eating fatty meal)
• Continuance of action: 4 to 5 hours
Cialis: 5 mg, 10 mg, 20 mg tablets
• Commencement of action: 16-45 minutes (food cannot be the reason of delay)
• Continuance of action: 36 hours
Viagra, Levitra and Cialis demand sexual stimulation to start their work. One should take Viagra on an empty belly, because it can increase the effect. Also it is not recommended to eat a lot of high-fat food in the period of time when taking Viagra. As Viagra does, Levitra also can lose its effectiveness if consuming a high-fat meal, however the food with abstemious concentrate of fat cannot be the reason of effect delays. In the case of Cialis you can pay attention on nothing what you eat. Cialis produces slower commencement of action but longer maintenance.
Those persons who want ingenuousness can wale Cialis that will guarantee the erection within 36 hours after taking. The significant longer useful life of Cialis allow patient not to take the medication in big doses and provide higher impulsion between lovers. Also this feature can cut to the bone the possibility of side effects.
In the case of Viagra, the suggested dose is 50 mg however your doctor can increase or decrease it against the particular patient. Levitra and Cialis are recommended to be taken in a dose of 10 mg and doctor can prescribe 20 mg if it is necessary. It is also possible to take 5 mg dose for those patients, who take other medications or unsatisfactory health condition. One can take Levitra in 2.5 mg dose. It is important to know that you cannot use any of abovementioned PDE-5 inhibitors oftener than once a day.
In spite of the fact that all three medications are quite safety, the possibility of after-effects still exists.
Most abundant after-effects:
• Viagra: face reddening, cephalalgia, dyspepsia
• Levitra: face reddening, cephalalgia
• Cialis: cephalalgia, dyspepsia
Not frequent after-effects:
• Viagra: problems with eyes, giddiness, stuffiness in nose
• Levitra: dyspepsia, sickness, giddiness, stuffiness in nose
• Cialis: backache, pain in muscles, stuffiness in nose, face reddening, giddiness
Safety measures and Counterindication
All three medicaments, Viagra, Levitra and Cialis are strongly forbidden to be taken by patients who use organic nitrates.
• Viagra has warning note, which informs that it is forbidden to take 50 mg or 100 mg doses in four hours after taking alpha-blocker. However patient can easily take 25 mg dose together with alpha-blocker, because it is not able to significantly decrease blood pressure.
• Levitra is contraindicated medicament for those persons who use alpha-blockers.
• Cialis is also contraindicated for those patients who use alpha-blockers, but with exception for tamsulosin (Flomax).
In view of the fact that Viagra and Levitra belong to medicaments that cause vasodilatory and hypotensive effects, it is forbidden to take them if patient has arterial or orthostatic hypotension.
Those persons who had heart seizure or any other serious problem with heart should abstain from taking Cialis within 6 months. Also doctor should decrease the dosage of Cialis for patiens who have problems with kidney or liver.
There are not many significant distinctions between Viagra, Levitra and Cialis. Any of these drugs appear to be effectual and harmless. If compare Levitra with Viagra, the first has not so much after-effects as the second and at the same time has the nearly equal features. Cialis has the least after-effect from all three PDE-5 inhibitors and remains in body longer. As the fact, the dose and frequency of taking can be decreased. But the lifetime of Cialis, that considers to be the longest among all three drugs can cause the risk of drug interactions.